Time from hospital admission to onset of septic shock is associated with higher in-hospital mortality

Link to article at PubMed

Shock. 2022 Aug 9. doi: 10.1097/SHK.0000000000001973. Online ahead of print.


OBJECTIVE: Several studies have shown septic shock developing later during the hospital stay is associated with higher mortality. However, the precise point at which time from hospital admission to the onset of septic shock (admission-shock-onset-time) becomes an independent prognostic marker of mortality remains unknown. This study evaluated the association between admission-shock-onset-time and in-hospital mortality among patients with septic shock and the optimal cut-off period to categorize early and late-onset septic shock.

METHOD: We conducted a single-center retrospective, observational cohort study at a quaternary academic hospital comprising adult patients with septic shock admitted to a medical intensive care unit (ICU) from 01/2011 to 12/2020. A multivariable additive logistic regression model was developed to assess if log-transformed admission-shock-onset-time was associated with in-hospital mortality. The thin plate spline function was used to describe the nonlinear relationship between the log-transformed admission-shock-onset-time and in-hospital mortality. The primary outcome was in-hospital mortality, and the secondary outcome was ICU mortality.

RESULTS: 2,520 patients met the inclusion criteria with an overall in-hospital mortality of 37.3%. The log-transformed admission-shock-onset-time was associated with higher in-hospital and ICU mortality even after adjusting for clinical variables. The odds ratio (OR) for in-hospital mortality continued to increase throughout the observation period. The adjusted OR exceeded 2 in-between 20.1 hours and 54.6 hours, and it surpassed 3 in-between 54.6 hours and 148.4 hours of the time from the hospital admission to shock onset.

CONCLUSION: In-hospital mortality continued to rise as admission-shock-onset-time increased in patients with septic shock. No clear dichotomization between early and late septic shock could be ascertained, and this categorization may limit our understanding of the temporal relationship of shock onset to mortality.

PMID:35959788 | DOI:10.1097/SHK.0000000000001973

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