Curr Ther Res Clin Exp. 2022 May 16:100675. doi: 10.1016/j.curtheres.2022.100675. Online ahead of print.
ABSTRACT
PURPOSE: In a phase III study, regdanvimab (CT-P59) reduced the risk of hospitalization or death versus placebo in patients with mild to moderate coronavirus disease 2019 (COVID-19). We performed a retrospective cohort study of patients with COVID-19 to examine the effect of regdanvimab versus standard of care (SoC) on oxygen saturation.
METHODS: We reviewed patients with mild to moderate COVID-19 confirmed by reverse transcription-polymerase chain reaction at a single hospital in the Republic of Korea. The primary efficacy endpoint was the proportion of patients deteriorating with peripheral capillary oxygen saturation (SpO2) <94% on room air up to day 28.
FINDINGS: A total of 127 patients were treated with regdanvimab, 190 with SoC. The proportion of patients deteriorating with SpO2 <94% on room air up to day 28 was 13.4% with regdanvimab and 39.5% with SoC (P<0.0001); median time (range) until sustained recovery of fever was 2.0 (0.2-14.8) and 4.2 (0.1-17.1) days, respectively. Supplemental oxygen was required by 23.6% of patients with regdanvimab and 52.1% with SoC (P<0.0001) for a mean of 6.3 and 8.7 days, respectively (P=0.0113); no patients needed mechanical ventilation. Compared with SoC, hospitalization was shorter with regdanvimab (mean 11.1 vs 13.6 days; 63.8% vs 31.6% discharged within 11 days; both P<0.0001). Fewer regdanvimab-treated patients required remdesivir (14.2% vs 43.2%; P<0.0001). There were no deaths. Two patients had adverse reactions with regdanvimab.
IMPLICATIONS: This real-world study indicates that regdanvimab can prevent deterioration in patients with mild to moderate COVID-19.
PMID:35601976 | PMC:PMC9109994 | DOI:10.1016/j.curtheres.2022.100675