Cutaneous Reactions to COVID-19 Vaccines: A Review

Link to article at PubMed

JAAD Int. 2022 Feb 17. doi: 10.1016/j.jdin.2022.01.011. Online ahead of print.


BACKGROUND: The increasing number of reports on cutaneous reactions following coronavirus disease (COVID-19) vaccination has led to growing concerns among certain groups.

OBJECTIVE: We reviewed published reports of cutaneous lesions after COVID-19 vaccination.

METHODS: We conducted a literature search for original and review articles published between January 1, 2020, and September 27, 2021.

RESULTS: Eleven cutaneous reactions associated with COVID-19 vaccines were determined; the most prevalent reactions were local injection site reactions, delayed local reactions, urticaria, angioedema, and morbilliform eruptions. There were more reports on skin reactions following mRNA-based vaccines compared to adenoviral vector or inactivated whole-virus vaccines, in part due to their higher administration rate. Most reported skin reactions occurred after the first vaccination dose.

LIMITATIONS: Reporting bias cannot be excluded, and skin biopsy results were not available for most included individuals. Moreover, given that the included trials focused on vaccine efficacy, there was a lack of details concerning cutaneous reactions and participant information.

CONCLUSION: Not all cutaneous reactions observed after COVID-19 vaccination are hypersensitivity reactions. Different cutaneous reactions may reflect underlying immune responses to vaccines. A large majority of COVID-19 vaccination reactions were mild and self-limiting, and people should be encouraged to complete their vaccination regimen.

PMID:35194586 | PMC:PMC8849859 | DOI:10.1016/j.jdin.2022.01.011

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