Initial Specimen Diversion Device® Reduces Blood Culture Contamination and Vancomycin Use in Academic Medical Center

Link to article at PubMed

J Hosp Infect. 2021 Nov 12:S0195-6701(21)00381-9. doi: 10.1016/j.jhin.2021.10.017. Online ahead of print.


BACKGROUND: In suspected bloodstream infections, accurate blood culture results are critical to timely diagnoses and appropriate antibiotic administration.

AIM: An Initial Specimen Diversion Device®, Steripath®, (Magnolia Medical Technologies, Seattle, WA) was evaluated for efficacy in reducing blood culture contamination at Brooke Army Medical Center (6.8% six-month contamination rate prior to intervention) in a six-month quality improvement project.

METHODS: Blood cultures in the emergency department were collected using either Steripath® or the standard method. 20 mL of blood was cultured into an aerobic and anaerobic medium and incubated for five days using an automated microbial detection system immediately after collection. Positive bottles were Gram stained and plated. Rapid molecular PCR identification was performed on all first positive bottles within a blood culture set for each admission or ED visit. Speciation was deduced during antimicrobial sensitivity testing using the Vitek-2 instrument.

FINDINGS: Seven (7/1016, 0.69%) contamination events occurred when using Steripath® vs. 53 (53/800, 6.6%) contamination events when using the standard method. Steripath® use was associated with a 90% lower incidence of blood culture contamination vs. the standard method. Post-study, Steripath® use was implemented as standard practice hospital-wide, and a retrospective data analysis attributed a 31.4% decrease in vancomycin days of therapy to Steripath® adoption.

CONCLUSION: Using Steripath® significantly decreased blood culture contamination events for bacterial bloodstream infections compared to the standard method. Subsequent adoption of Steripath® reduced overall vancomycin usage. With widescale implementation Steripath® could bolster antibiotic stewardship, mitigating antibiotic resistance caused by unnecessary antibacterial treatments.

PMID:34780808 | DOI:10.1016/j.jhin.2021.10.017

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