Safety and Effectiveness of SARS-CoV-2 Vaccines: A Systematic Review and Meta-Analysis

Link to article at PubMed

J Med Virol. 2021 Jul 15. doi: 10.1002/jmv.27203. Online ahead of print.


OBJECTIVE: To systematically evaluate the effectiveness and safety of the SARS-CoV-2 vaccines currently undergoing clinical trials.

METHODS: Search PubMed, EMBASE, Cochrane Library database, collect open human COVID-19 vaccines randomized controlled trials (RCT), without limiting the search time and language. The researches collected in the above-mentioned databases were merged, repeated researches were removed, and the researches were initially screened according to the title and abstract content. After reading the full text of the remaining research, the studies that did not meet the inclusion criteria were excluded, and finally 9 studies were obtained. After extracting the statistical data of adverse events in the study, load them into Review Manager for heterogeneity analysis.

RESULTS: The incidence of adverse reactions of inactivated virus vaccines, RNA vaccines and adenovirus vector vaccines was higher than that of placebo. Common adverse reactions included pain, swelling and fever at the injection site.

CONCLUSION: From the perspective of effectiveness, RNA vaccine>Adenovirus vector vaccine>Inactivated virus vaccine; From the perspective of safety, the incidence of adverse reactions of the three vaccines is higher than that of placebo, and the incidence of adverse reactions of the adenovirus vector vaccine is higher. This article is protected by copyright. All rights reserved.

PMID:34264528 | DOI:10.1002/jmv.27203

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