Evaluation of rapid antigen tests based on saliva for the detection of SARS-CoV-2

Link to article at PubMed

J Med Virol. 2021 Mar 31. doi: 10.1002/jmv.26983. Online ahead of print.

ABSTRACT

Rapid identification and isolation of with SARS-CoV-2 infected individuals is crucial. Recent studies have shown that RT-PCR from self-collected saliva is a suitable alternative to nasopharyngeal swab. A disadvantage of RT-PCR resulting in a long time until result which may be problematic. To address this problem, in this study a rapid antigen testCE-certified for the detection of SARS-CoV-2 using saliva (COVID-19 Antigen Test Cassette (hypersensitive colloidal gold) was evaluated. An overall sensitivity of saliva rapid antigen test of 44.4% and a specificity of 100% compared with RT-PCR-results from gargle solution as gold standard was shown. The data suggests that rapid antigen tests based on saliva for the detection of SARS-CoV-2 are not a no reliable substitute for RT-PCR. This article is protected by copyright. All rights reserved.

PMID:33788280 | DOI:10.1002/jmv.26983

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