Refractory Anaphylaxis: Treatmentalgorithm

Link to article at PubMed

Allergy. 2021 Feb 16. doi: 10.1111/all.14780. Online ahead of print.


There is no established definition for refractory anaphylaxis. The European Anaphylaxis Registry use a definition of "anaphylaxis which, despite treatment with at least two doses of minimum 300μg adrenaline, does not achieve normalization" of symptoms.1 A USA-based panel recently proposed a reaction which "must be treated with 3+ appropriate doses of epinephrine (or initiation of an intravenous epinephrine infusion)"2 - a definition which does not specifically refer totreatment response, although this is implied.

PMID:33594699 | DOI:10.1111/all.14780

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