2021 Mar 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–.
Factor V Leiden (FVL) is a point mutation of factor V resulting in an elimination of cleavage site in factor V and factor Va. This genetic defect leads to an increased risk of thrombosis especially in homozygous or pseudo-homozygous FVL mutations. Many individuals with the mutation will never develop a venous thrombotic event (VTE). The decision about VTE risk reduction (both primary and secondary and prevention of recurrence) requires a great deal of clinical acumen, given that most of the people who carry the mutation will never have VTE.