Clinical Course of 195 Critically ILL COVID-19 Patients, A Retrospective Multi-Center Study

Link to article at PubMed

Shock. 2020 Aug 20. doi: 10.1097/SHK.0000000000001629. Online ahead of print.


INTRODUCTION: Coronavirus disease-2019 (COVID-19) outbreak has spread around the world. However, the dynamic course of critically ill COVID-19 has not been described thoroughly.

MATERIALS AND METHODS: We retrospectively analyzed 195 critically ill COVID-19 patients in Hubei province, China, between January 5, 2020 and April 3, 2020. Epidemiologic data, clinical features, treatments and outcomes were collected and analyzed.

RESULTS: Most critically ill patients were older with higher Acute Physiology and Chronic Health Evaluation II (APACHE II) scores. After critical illness onset, a total of 181 (92.8%) patients received ventilation support, of which 84 (43.1%) received non-invasive and 97 (49.7%) received invasive mechanic ventilation (IMV). Among the 97 patients with IMV, 28 (28.9%) received prone ventilation, 57 (58.8%) received neuromuscular blocked therapy and 22 (11.3%) received tracheostomy due to prolonged ventilator use. Early hypoxemia, subsequent hypercapnia, pulmonary hypertension, and finally pulmonary fibrosis were notable in the clinical course of acute respiratory distress syndrome (ARDS). Eighty-nine (45.6%) patients presented with shock. Acute kidney injury (29.7%) and secondary infection (28.2%) were also notable. The overall mortality of critically ill patients at day 28 was 42.1%. ICU mortality was around 33%, as 16 patients died prior to ICU admission. A low PaO2/FiO2 ratio was an independent risk factor for death. High viral load was observed in most non-survivors.

CONCLUSION: ARDS and shock were notable in the critical illness of COVID-19. Ventilation support and hemodynamic support were the cornerstones for critical care. High viral load was associated with death of critically ill COVID-19 patients.

PMID:32826818 | DOI:10.1097/SHK.0000000000001629

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