Dermatol Ther. 2020 Aug 8:e14157. doi: 10.1111/dth.14157. Online ahead of print.
BACKGROUND: COVID-19 diseases have been a nationwide pandemic condition. However, cutaneous, skin histopathological manifestations of COVID-19 infection are not well described. Our study aims are to present heterogeneous cutaneous, histopathological manifestations in COVID-19 patients, to investigate the possible relationship between cutaneous manifestations and histopathological features in COVID-19 infection.
MATERIALS AND METHODS: We performed a systemic review in PubMed database and Chinese medical journal search engines which were wangfang.data (http://www.wanfangdata.com.cn/), Science China (http://www.cnki.net/) until June 17th , 2020. Search terms "COVID-19", "SARS-Coronavirus-2" and "Coronavirus" were used in combination with "cutaneous", "rash", "skin", "dermatology".
RESULTS: 75 papers were included with confirmed COVID-19 infection. The most frequent cutaneous manifestation of COVID-19 present was erythema, nearly 38.4%. Trunk was the most affected location, presenting in 51.4% patients. Rash occurred before onset of other symptoms was in 5.3% patients. 77 patients were received treatments. Rash was dismissed in 49% patients, improved in 21.2% patients ranged from 0-17 days. The histopathological examination present in 39 patients.
CONCLUSION: Skin is one of target organs affected by COVID-19 infection. Cutaneous manifestations should be paid more attention. It can help doctors diagnose COVID-19 infection in prodromal stage, understand progression, and determine prognosis of COVID-19 infection. This article is protected by copyright. All rights reserved.