Use of the IL-6R Antagonist Tocilizumab in Hospitalized COVID-19 Patients

Link to article at PubMed

J Intern Med. 2020 Aug 3. doi: 10.1111/joim.13163. Online ahead of print.


Severely ill COVID-19 patients have a high risk of admission to the intensive-care unit (ICU) and requirement for mechanical ventilation (MV), with in-hospital mortality reported as 18-79% globally.1-4 . Among ICU patients in the United States (US), centers have reported 50% mortality.5,6 Tocilizumab, an IL-6 receptor (IL-6R) antagonist, is FDA approved for the management of CAR T-cell related Cytokine Release Syndrome (CRS) and may have utility in treatment of some COVID-19 patients. We describe the clinical characteristics and initial outcomes of a cohort of patients treated with tocilizumab at the Swedish Medical Center in Seattle, Washington.

PMID:32745348 | DOI:10.1111/joim.13163

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