Li H and Hu P. Zhonghua Gan Zang Bing Za Zhi 2020.
COVID-19 has been prevalent in many countries and regions of the world since the end of December 2019. Studies have shown that SARS-CoV-2 infects the human body and replicates effectively through angiotensin-converting enzyme II (ACE2). ACE2 is widely distributed in various tissues and organs of the human body, such as intestinal epithelial cells, cardiomyocytes, renal tubular epithelial cells, and testicular stromal cells, etc. This could be one of the reasons for the diversity of clinical manifestations of COVID-19, or it may be the cause of accelerated disease progression and multi-system damage. This article reviews the clinical manifestations of COVID-19 related to the extrapulmonary system such as digestive, circulatory, urogenital, hematopoietic and nervous.