Jalota R and Soos MP. StatPearls. StatPearls Publishing 2020 Jan– - Review.
Subclavian vein thrombosis (SCVT) is a condition where a blood clot forms in the subclavian vein. SCVT can occur from multiple etiologies and is a potentially life-threatening pathology if not treated in a timely manner. SCVT occurs due to either a primary etiology or a secondary etiology. Primary thrombosis is further delineated as effort induced (Paget-Schroetter syndrome) or idiopathic (frequently associated with undiagnosed malignancy). Secondary subclavian vein thrombosis is associated with catheters or lines in the vein. While primary thrombosis is rare, the incidence of secondary thrombosis continues to rise as a consequence of complex cardiac devices and long term central venous catheters (CVC) placement in cancer patients. SCVT has high rates of acute mortality and long term disability without proper and timely treatment. Early diagnosis and treatment are essential in preventing fatal acute complications, such as pulmonary embolism and long term morbidity related to venous inflow restriction.