Cytokine Storm in COVID19: A Neural Hypothesis

Link to article at PubMed

Ur A and Verma K. ACS Chem Neurosci 2020.

ABSTRACT

Cytokine storm in COVID-19 is characterized by an excessive inflammatory response to SARS-CoV-2 that is caused by a dysregulated immune system of the host. We are proposing a new hypothesis that SARS-CoV-2 mediated inflammation of nucleus tractus solitarius (NTS) may be responsible for the cytokine storm in COVID 19. The inflamed NTS may result in a dysregulated cholinergic anti-inflammatory pathway and hypothalamic-pituitary-adrenal axis.

PMID:32605374 | DOI:10.1021/acschemneuro.0c00346

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