Prognostic Value of Hormonal Abnormalities in Heart Failure Patients.
Heart Fail Clin. 2019 Jul;15(3):371-375
Authors: Gargiulo P, Paolillo S, Ferrazzano F, Prastaro M, La Mura L, De Roberto AM, Diana G, Dell'Aversana S, Contiello C, Vozzella MC, Bardi L, Marsico F
The model used to explain the pathophysiologic substrate and progressive worsening in chronic heart failure (CHF) is based on the hyperactivity of renin-angiotensin-aldosterone system and adrenergic pathway. Although the neurohormonal medical approach has many advantages, it has several pitfalls, as demonstrated by high rates of CHF mortality and hospitalization. A growing body of evidence has led to the hypothesis that CHF is a multiple hormone deficiency syndrome, characterized by a reduced anabolic drive that has relevant functional and prognostic implications. The aim of this review is to summarize the evidence of reduced drive of main anabolic axes in CHF.
PMID: 31079695 [PubMed - in process]