Mechanisms and Management of Asthma Exacerbations.
Am J Respir Crit Care Med. 2018 Dec 18;:
Authors: Ramsahai JM, Hansbro PM, Wark PAB
Acute asthma remains an important medical emergency, the most frequent cause of acute admissions in children and a major source of morbidity for adults with asthma. In all ages with asthma the presence of exacerbations is an important defining characteristic of asthma severity. In this review we will assess the epidemiology of acute asthma, the triggers of acute exacerbations and the mechanisms that underlie these exacerbations. We will also assess current treatments that prevent exacerbations, with an emphasis on the role of type 2 airway inflammation in the context of acute exacerbations and the novel treatments that effectively target this. Finally we will review current management strategies of the exacerbations themselves.
PMID: 30562041 [PubMed - as supplied by publisher]