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A Statewide Antibiotic Stewardship Collaborative to Improve the Diagnosis and Treatment of Urinary Tract and Skin and Soft Tissue Infections.
Clin Infect Dis. 2018 Mar 30;:
Authors: Jenkins TC, Hulett T, Knepper BC, Shihadeh KC, Meyer MJ, Barber GR, Hammer JH, Wald HL
Abstract
Background: Colorado hospitals participated in a statewide collaborative to improve the diagnosis and treatment of inpatient urinary tract infections (UTI) and skin and soft tissue infections (SSTI). We evaluated the effects of the intervention on diagnostic accuracy and antibiotic use.
Methods: The collaborative outcomes were: (1) proportion of UTI diagnoses meeting criteria for symptomatic UTI; (2) exposure to fluoroquinolones (UTI only); (3) duration of therapy (UTI and SSTI); and (4) exposure to antibiotics with broad gram-negative activity (SSTI only). Outcomes were compared between pre-intervention and intervention periods overall and by hospital. In a secondary analysis, changes in outcome trends were evaluated by time series analysis.
Results: 26 hospitals, including 9 critical access hospitals, participated in the collaborative. Data were reported for 4060 UTIs and 1759 SSTIs. Between the pre-intervention and intervention periods, the proportion of diagnosed UTIs meeting criteria for symptomatic UTI was similar (51% vs. 54%, respectively, p = 0.10), exposure to fluoroquinolones declined (49% vs. 41%, p<.001), and the median duration of therapy was unchanged (7 vs. 7 days, p=.99). Among SSTIs, exposure to antibiotics with broad gram-negative activity declined (61% vs. 53%, p=0.001) and the median duration of therapy declined (11 vs. 10 days, p=0.03). There was substantial variation in performance among hospitals. By time series analysis, only the declining trend of fluoroquinolone use was significant (p=0.03).
Conclusion: The collaborative model is a feasible approach to engage hospitals in a common antibiotic stewardship intervention. Performance improvement was observed for several outcomes overall but varied substantially by hospital.
PMID: 29617742 [PubMed - as supplied by publisher]