Relative Abundance of Extended-Spectrum Beta-Lactamase-producing Escherichia coli in the Gut of Patients Admitted in Hospitals: a Prospective Cohort Study Overtime.
Antimicrob Agents Chemother. 2016 Sep 6;
Authors: de Lastours V, Chopin D, Jacquier H, d'Humières C, Burdet C, Chau F, Denamur E, Fantin B
Four-hundred-fifty-eight patients were prospectively included at hospital admission and screened for ESBL-E. coli carriage in 2007 and 2010-12. A 4-fold increase in ESBL carriage (3% to 12%), a 5-fold increase in numbers of community patients among ESBL-carriers and a higher number of multiple ESBL-strains was found in 2010-12. ESBL-E. coli represented the dominant E. coli strain (relative abundance>50%) in 10/32 (31%) ESBL-carriers. This represents a major threat in terms of infectious risk and dissemination.
PMID: 27600033 [PubMed - as supplied by publisher]