Management of Acute Kidney Injury and Acid-Base Balance in the Septic Patient.
Clin Chest Med. 2016 Jun;37(2):277-88
Authors: Weyker PD, Pérez XL, Liu KD
Acute kidney injury (AKI) is an abrupt decrease in kidney function that takes place over hours to days. Sepsis is the leading cause of AKI and portends a particularly high morbidity and mortality, although the severity may vary from a transient rise in serum creatinine to end-stage renal disease. With regard to acid-base management in septic AKI, caution should be used with hyperchloremic crystalloid solutions, and dialysis is often used in the setting of severe acidosis. In the future, biomarkers may help clinicians identify AKI earlier and allow for potential interventions before the development of severe AKI.
PMID: 27229644 [PubMed - in process]