Neutrophil/lymphocyte ratio is associated with right ventricular dysfunction in patients with acute inferior ST elevation myocardial infarction.
Cardiol J. 2015 Sep 28;
Authors: Yaylak B, Ede H, Baysal E, Altıntas B, Akyuz S, Sevuk U, Erdoğan G, Comert N, Cakmak OE, Altındag R, Karahan Z, Bilge O, Cevik K
BACKGROUND: Acute inferior ST elevation myocardial infarction (STEMI) is associated with increased in-hospital morbidity and mortality particularly among patients with coexisting right ventricular (RV) involvement. High neutrophil lymphocte ratio (NLR) is an independent predictor of major adverse cardiac events (MACE) and mortality in patients with myocardial infarction (MI). This study evaluated the relationship between the NLR and RV dysfunction in patients with inferior STEMI who undergone primary Percutaneous Coronary İntervention (PCI).
METHODS: A total of 213 subjects with inferior STEMI were divided into two groups according to the presence of RV dysfunction. The groups were compared according to NLR and receiving operating characteristics (ROC) analysis was performed to access the predictability of NLR on having RV dysfunction.
RESULTS: The NLR was significantly higher in the group with RV dysfunction compared to that without RV dysfunction (p<0.001). In ROC analysis, NLR>3.5 predicted RV dysfunction with sensitivity of 83% and specificity of 55%. In a multivariate regression analysis, NLR remained an independent predictor of RV dysfunction (OR:1.55, 95% confidence interval 1.285-1.750; p<0.001).
CONCLUSIONS: NLR was an independent predictor of RV dysfunction in patients with inferior STEMI undergoing primary PCI.
PMID: 26412608 [PubMed - as supplied by publisher]