History of diabetes mellitus is associated with elevated cardiac troponin I levels in patients with chest pain but no coronary heart disease.
Cardiol J. 2015 Oct 27;
Authors: Zhong B, Wang Y, Zhang G
BACKGROUND: The factors and the mechanism contributing to increases in cardiac troponin I (cTnI) in patients with chest pain, at least one cardiovascular risk factor, and no evidence of coronary heart disease (CHD) remains elusive.
METHODS: Excluding patients with acute coronary syndrome and chronic myocardial ischemia, we selected 362 consecutive patients with normal coronary angiography (CAG) or computed tomography coronary angiography (CTCA) results or lesions causing <50% stenosis in any one of the coronary arteries from January 2012 to June 2015. Using a cut-off value of 0.01 ng/ml, patients with cTnI levels ≥ 0.01 ng/mL (164 patients) were compared with those with cTnI levels < 0.01 ng/mL. Logistic regression analysis was used to evaluate associations between elevated cTnI and patient characteristics.
RESULTS: Other than history of diabetes mellitus (18.90% vs. 8.08%, P = 0.002), the characteristics of the patients with and without elevated cTnI levels were similar. History of diabetes mellitus predicted elevation of cTnI level (OR = 3.34, 95% CI = 1.55-7.20, P = 0.002) in logistic regression analysis.
CONCLUSIONS: In total, 45.30% of patients with chest pain had elevated cTnI levels with a mean level of 0.07 ± 0.10 ng/mL. History of diabetes mellitus rather than blood glucose level itself was associated with elevated cTnI levels, whereas female gender was protective against increases in cTnI levels.
PMID: 26503081 [PubMed - as supplied by publisher]