Addition of Simvastatin to Standard Therapy for the Prevention of Variceal Rebleeding Does not Reduce Rebleeding but Increases Survival in Patients With Cirrhosis.
Gastroenterology. 2016 Jan 13;
Authors: Abraldes JG, Villanueva C, Aracil C, Turnes J, Hernandez-Guerra M, Genesca J, Rodriguez M, Castellote J, García-Pagán JC, Torres F, Calleja JL, Albillos A, Bosch J, BLEPS study group
BACKGROUND & AIMS: The combination of β-blockers and band ligation is the standard approach to prevent variceal rebleeding, but bleeding recurs and mortality is high. The lipid-lowering drug simvastatin decreases portal pressure, improves hepatocellular function, and might reduce liver fibrosis. We assessed whether adding simvastatin to standard therapy could reduce rebleeding and death after variceal bleeding in patients with cirrhosis.
METHODS: We performed a multicenter, double-blind, parallel trial of 158 patients with cirrhosis receiving standard prophylaxis to prevent rebleeding (a β-blocker and band ligation) in Spain from October 2010 through October 2013. Within 10 days of bleeding, subjects were randomly assigned, but stratified by Child-Pugh scores of A or B vs C, to groups given simvastatin (20 mg/day the first 15 days, 40 mg/day thereafter; n=69) or placebo (n=78). Patients were followed for as long as 24 months. The primary endpoint was a composite of rebleeding and death, and main secondary endpoints were the individual components of the composite (death and rebleeding) RESULTS: The primary endpoint was met by 30/78 patients in the placebo group and 22/69 in the simvastatin group (P=.423). Seventeen patients in the placebo group died (22%) vs 6 patients in the simvastatin group (9%) (hazard ratio for adding simvastatin to therapy, 0.39; 95% confidence interval, 0.15-0.99; P=.030). Simvastatin did not increase survival of patients with Child-Pugh class C cirrhosis. Rebleeding occurred in 28% of patients in the placebo group and 25% in the simvastatin group (P=.583). Serious adverse events occurred in 53% of patients in the placebo group and 49% in the simvastatin group (P=.752); the percentages of serious adverse events related to therapy were 11% in the placebo group vs 8% in the in the simvastatin group (P=.599). Two patients in the simvastatin group, each with advanced liver disease, developed rhabdomyolysis.
CONCLUSION: In a randomized controlled trial, addition of simvastatin to standard therapy did not reduce rebleeding but was associated with a survival benefit for patients with Child-Pugh class A or B cirrhosis. Survival was not the primary endpoint of the study, so these results require validation. The incidence of rhabdomyolisis in patients receiving 40 mg/day simvastatin was higher than expected. European Clinical Trial Database no: EUDRACT 2009-016500-24.
PMID: 26774179 [PubMed - as supplied by publisher]