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ACTIVITY OF FOSFOMYCIN FOR ESBL UROPATHOGENS IN COMMUNITY AND HOSPITALIZED PATIENTS.
Antimicrob Agents Chemother. 2015 Nov 23;
Authors: Linsenmeyer K, Strymish J, Weir S, Berg G, Brecher S, Gupta K
Abstract
Few oral antibiotics exist for empiric treatment of extended-spectrum beta lactamase (ESBL) UTI. We sought to determine the activity of fosfomycin for ESBL uropathogens from patients at 3 VA facilities between 2010-2013. Among ESBL uropathogens, 21.6% were fosfomycin resistant. Klebsiella species were more likely than E. coli to be resistant (46% vs. 4%, p <.001). Fosfomycin remains active against a majority of ESBL uropathogens, although resistance among Klebsiella sp was higher than in previous reports.
PMID: 26596940 [PubMed - as supplied by publisher]