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Comorbid Risks of Deep Vein Thrombosis and Pulmonary Thromboembolism in Patients With Chronic Pancreatitis: A Nationwide Cohort Study.
J Thromb Haemost. 2015 Nov 12;
Authors: Chung WS, Lin CL
Abstract
BACKGROUND: Studies on the association between chronic pancreatitis (CP) and cardiovascular diseases are scant. We conducted a nationwide cohort study to evaluate the risks of deep vein thrombosis (DVT) and pulmonary embolism (PE) in CP patients.
METHODS: Using the data from the Taiwan National Health Insurance Research Database, we randomly selected a non-CP cohort from insurants without a history of CP and frequency-matched them at a ratio of 4:1 according to age, sex, and index year with each patient newly diagnosed with CP between 2000 and 2010. The follow-up period ranged from the index date of new CP diagnosis to the diagnosis of DVT or PE, censoring, or the end of 2011. We conducted Univariable and multivariable Cox proportional hazard regression models to determine the risks of DVT and PE.
RESULTS: In total, 17 778 patients in the CP cohort (82.6% men, mean age = 48.6 y) and 71 106 persons in the non-CP cohort were observed for 86 740 and 429 116 person-years, respectively. The CP cohort exhibited a 2.95-fold greater adjusted hazard ratio (aHR) of DVT (95% confidence interval [CI] = 2.06-4.22) and a 4.51-fold greater aHR of PE (95% CI = 2.86-7.11) than those of the non-CP cohort. Substantial risks of DVT and PE were evident in patients with CP aged <55 years. The CP cohort with comorbidities showed increased risks of DVT and PE compared with the non-CP cohort with no comorbidity.
CONCLUSIONS: The risks of DVT and PE are significantly higher in CP patients than in the general population. This article is protected by copyright. All rights reserved.
PMID: 26563680 [PubMed - as supplied by publisher]