Antibiotic Resistance - Problems, Progress, and Prospects.
N Engl J Med. 2014 Oct 1;
Authors: Nathan C, Cars O
Two major ways that modern medicine saves lives are through antibiotic treatment of severe infections and the performance of medical and surgical procedures under the protection of antibiotics. Yet we have not kept pace with the ability of many pathogens to develop resistance to antibiotics that are legacies of the golden era of antibiotic discovery, the 1930s to 1960s. We call that period "golden" because success seemed routine then; we call it an "era" because it ended. When industry scientists shifted from making variants of old drugs to pursuing fundamentally new drugs with activity against resistant pathogens, they generally failed. . . .
PMID: 25271470 [PubMed - as supplied by publisher]