Evaluation of pharmacist-managed dabigatran in an inpatient setting.
Ann Pharmacother. 2013 Dec;47(12):1649-53
Authors: Tedders KM, Lucey MF, Edwin SB
BACKGROUND: Although therapeutic drug monitoring is not required for patients receiving dabigatran to determine therapeutic efficacy, there are a number of other factors to consider. Currently, there are no studies evaluating pharmacist-led management of dabigatran.
OBJECTIVE: The role of inpatient pharmacists related to the management of dabigatran was evaluated.
METHODS: All adult patients who received at least 1 dose of dabigatran with a length of stay greater than 24 hours in a single-center, community hospital between May 2011 and August 2012 were retrospectively reviewed (n = 176).
RESULTS: Almost half of the patients (46%) required pharmacist intervention related to dabigatran management during hospital admission. Of patients receiving dabigatran prior to hospital admission, 18.4% were admitted on an inappropriate home dose. Transitioning between dabigatran and alternative anticoagulants accounted for the majority of pharmacist interventions (74.2%), with patients transitioning from unfractionated heparin to dabigatran occurring most frequently. Renal impairment requiring dose adjustment or drug discontinuation occurred in 6.3% of patients, whereas 6.8% of patients required pharmacist intervention for procedural anticoagulation. Inpatient therapy was determined to be relatively safe, with few patients (1.7%) requiring permanent discontinuation of dabigatran as a result of a bleeding complication.
CONCLUSION: Pharmacists significantly contributed to the safe and appropriate use of dabigatran during hospitalization.
PMID: 24259619 [PubMed - indexed for MEDLINE]