Heparin-induced thrombocytopenia.

Link to article at PubMed

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Heparin-induced thrombocytopenia.

Hematology Am Soc Hematol Educ Program. 2013;2013:668-74

Authors: Lee GM, Arepally GM

Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder caused by antibodies that recognize complexes of platelet factor 4 (PF4) and heparin. HIT is frequently considered in the differential diagnosis of thrombocytopenia occurring in patients on heparin therapy. HIT is a challenging diagnosis because of routine heparin use in hospitalized patients, the common occurrence of thrombocytopenia, and high rates of anti-PF4/heparin seroconversions in patients treated with heparin. Our diagnostic approach to HIT is presented here, underscoring critical elements of clinical and laboratory evaluation.

PMID: 24319250 [PubMed - indexed for MEDLINE]

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