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Drug Induced Liver Injury Associated with Daptomycin: A Case Report and Cohort Analysis.
Antimicrob Agents Chemother. 2014 May 12;
Authors: Bohm N, Makowski C, Machado M, Davie A, Seabrook N, Wheless L, Bevill B, Clark B, Kyle TR
Abstract
A patient receiving daptomycin developed asymptomatic transaminitis and hyperbilirubinemia without concurrent multi-organ dysfunction or creatinine kinase elevation. After ruling out other etiologies, the liver injury was attributed to daptomycin and subsequently resolved. A single-center retrospective cohort analysis of all admissions during which daptomycin was administered from 2008 to 2013 with baseline and follow up liver function panels (n= 614) did not reveal any other cases of probable or definite drug-induced liver injury associated with daptomycin.
PMID: 24820087 [PubMed - as supplied by publisher]