Fatal association of mechanical valve thrombosis with dabigatran: a report of two cases.

Link to article at PubMed

Fatal association of mechanical valve thrombosis with dabigatran: a report of two cases.

Chest. 2013 Jul 1;144(1):327-8

Authors: Atar S, Wishniak A, Shturman A, Shtiwi S, Brezins M

Abstract
Several new oral anticoagulants have been approved for thromboembolism prevention in patients with nonvalvular atrial fibrillation. However, they are not yet approved for anticoagulation use in patients with prosthetic mechanical valves, and no randomized data have been published so far on their safety of use in these patients. We present two cases of patients with prosthetic mechanical mitral valves who were switched from warfarin and acenocoumarol to dabigatran and within 1 month experienced severe valve complications resulting in death. One patient experienced stroke and later cardiogenic shock and death, and the other experienced pulmonary edema, cardiogenic shock, and subsequent death.

PMID: 23880682 [PubMed - in process]

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