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Association of Beta-Blocker Use and Selectivity With Outcomes in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease (from OPTIMIZE-HF).
Am J Cardiol. 2012 Nov 29;
Authors: Mentz RJ, Wojdyla D, Fiuzat M, Chiswell K, Fonarow GC, O'Connor CM
Abstract
In patients with heart failure (HF) with chronic obstructive pulmonary disease (COPD), concerns exist regarding ? blockers, particularly noncardioselective ? blockers, precipitating bronchospasm or attenuating the benefit of inhaled ?(2) agonists. The aim of this study was to test the hypothesis that noncardioselective ? blockers would not be associated with worse outcomes compared with cardioselective ? blockers in patients with concomitant COPD in a large HF registry. A retrospective analysis of patients from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure (OPTIMIZE-HF) who had systolic dysfunction, documentation of ?-blocker status, and follow-up information available after index hospitalization (n = 2,670) was performed. The associations between cardioselective and noncardioselective ? blockers and the end points of 60- to 90-day mortality and mortality or rehospitalization in patients with (n = 722) and without (n = 1,948) COPD were analyzed using regression modeling. The models were adjusted for covariate predictors of ?-blocker use at discharge and clinical predictors of outcomes. Noncardioselective and cardioselective ? blockers were associated with lower risk-adjusted mortality in patients with and without COPD. There was no evidence that ?-blocker selectivity was associated with a difference in outcomes between patients with and those without COPD (p for interaction >0.10 for both outcomes). In conclusion, despite concerns regarding ? blockers in patients with HF with COPD, there was no evidence that ?-blocker selectivity was associated with differences in outcomes for patients with HF with COPD versus those without.
PMID: 23200803 [PubMed - as supplied by publisher]