From Clinical Observation to Mechanism - Heyde's Syndrome.
N Engl J Med. 2012 Nov 15;367(20):1954-1956
Authors: Loscalzo J
In 1958, E.C. Heyde noted an association between aortic-valve stenosis and GI bleeding, which led to identification of the mechanism of the bleeding: fragmentation of high-molecular-weight multimers of von Willebrand factor on the stenotic valve led to acquired von Willebrand's disease.
PMID: 23150964 [PubMed - as supplied by publisher]