Daptomycin Non-susceptible (DNS) Vancomycin Intermediate Staphylococcus aureus (VISA) Vertebral Osteomyelitis Cases Complicated by Bacteremia Treated with High-Dose Daptomycin and Trimethoprim-Sulfamethoxazole.
Antimicrob Agents Chemother. 2012 Aug 6;
Authors: Avery LM, Steed ME, Woodruff AE, Hasan M, Rybak MJ
We report two cases of daptomycin non-susceptible (DNS) vancomycin intermediate Staphylococcus aureus (VISA) vertebral osteomyelitis cases complicated by bacteremia treated with high dose daptomycin and trimethoprim-sulfamethoxazole. Both patients responded rapidly and favorably to this combination. The two patient's clinical isolates were tested post hoc in an in vitro PK/PD model to confirming the bactericidal activity and enhancement of daptomycin and trimethoprim-sulfamethoxazole. The combination of high dose daptomycin and trimethoprim-sulfamethoxazole should be further explored for the treatment of DNS VISA strains.
PMID: 22869580 [PubMed - as supplied by publisher]