Evaluation and differential diagnosis of marked, persistent eosinophilia.
Semin Hematol. 2012 Apr;49(2):149-59
Authors: Mejia R, Nutman TB
High-grade eosinophilia can be a diagnostic dilemma, as the etiologies are extensive and varied. Hypereosinophilic syndromes (HES) are a group of heterogeneous disorders, many of which remain poorly defined. By definition, HES must be distinguished from other disorders with persistently elevated eosinophilia with a defined cause. Although marked eosinophilia worldwide is most commonly caused by helminth (worm) infections, non-infectious causes must be considered, and include drug reactions, malignancies, and immunologic, inflammatory and allergic diseases.
PMID: 22449625 [PubMed - indexed for MEDLINE]