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Switching patients from clopidogrel to prasugrel in acute coronary syndrome. Effects of prasugrel loading dose on residual platelet reactivity.
J Thromb Haemost. 2012 Jul 2;
Authors: Lhermusier T, Voisin S, Mejean S, Garcia C, Sié P, Carrié D
Abstract
A combination of aspirin and P2Y12 inhibitors (thienopyridine or ticagrelor) is recommended with a high level of evidence for the treatment of acute coronary syndrome (ACS) [1, 2]. The TRITON TIMI38 study [3, 4] has shown that, compared to clopidogrel, prasugrel, a third generation thienopyridine P2Y12 blocker, decreases recurrence of ischemic events in ACS. In stable patients receiving a maintenance dose of clopidogrel, switching from clopidogrel to prasugrel is associated with increased platelet inhibition and this effect is obtained within 2 h when a loading dose of 60 mg prasugrel is given [5]. é 2012 International Society on Thrombosis and Haemostasis.
PMID: 22747669 [PubMed - as supplied by publisher]