Beta-block the septic heart.

Link to article at PubMed

Beta-block the septic heart.

Crit Care Med. 2010 Oct;38(10 Suppl):S608-12

Authors: Rudiger A

Cardiac depression is a well-described manifestation of the sepsis syndrome. An important underlying mechanism is the attenuation of the adrenergic response at the cardiomyocyte level. By reducing their cell-specific function (contractility), the cardiomyocytes reduce their energy expenditure. Consequently, the cardiac myocytes survive in a hibernation-like state as long as intracellular energy generation is limited. The objective of this study was to review ?-blocker therapy for the treatment of septic patients.

PMID: 21164404 [PubMed - in process]

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