Early prediction of septic shock in hospitalized patients.
J Hosp Med. 2010 Jan 8;5(1):19-25
Authors: Thiel SW, Rosini JM, Shannon W, Doherty JA, Micek ST, Kollef MH
BACKGROUND:: Hospitalized patients who develop severe sepsis have significant morbidity and mortality. Early goal-directed therapy has been shown to decrease mortality in severe sepsis and septic shock, though a delay in recognizing impending sepsis often precludes this intervention. OBJECTIVE:: To identify early predictors of septic shock among hospitalized non-intensive care unit (ICU) medical patients. DESIGN:: Retrospective cohort analysis. SETTING:: A 1200-bed academic medical center. PATIENTS:: Derivation cohort consisted of 13,785 patients hospitalized during 2005. The validation cohorts consisted of 13,737 patients during 2006 and 13,937 patients from 2007. INTERVENTION:: Development and prospective validation of a prediction model using Recursive Partitioning And Regression Tree (RPART) analysis. METHODS:: RPART analysis of routine laboratory and hemodynamic variables from the derivation cohort to identify predictors prior to the occurrence of shock. Two models were generated, 1 including arterial blood gas (ABG) data and 1 without. RESULTS:: When applied to the 2006 cohort, 347 (54.7%) and 121 (19.1%) of the 635 patients developing septic shock were correctly identified by the 2 models, respectively. For the 2007 patients, the 2 models correctly identified 367 (55.0%) and 102 (15.3%) of the 667 patients developing septic shock, respectively. CONCLUSIONS:: Readily available data can be employed to predict non-ICU patients who develop septic shock several hours prior to ICU admission. Journal of Hospital Medicine 2010;5:19-25. (c) 2010 Society of Hospital Medicine.
PMID: 20063402 [PubMed - as supplied by publisher]