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Impact of Chronic Liver Disease on Outcomes of Hospitalized Patients with COVID-19: A Multicenter United States Experience.
Liver Int. 2020 Jun 25;:
Authors: Hashemi N, Viveiros K, Redd WD, Zhou JC, McCarty TR, Bazarbashi AN, Hathorn KE, Wong D, Njie C, Shen L, Chan WW
Abstract
Liver injury has been described with COVID-19, and early reports suggested 2-11% of patients had chronic liver disease (CLD). In this multi-center retrospective study, we evaluated hospitalized adults with laboratory-confirmed COVID-19 and the impact of CLD on relevant clinical outcomes. Of 363 patients included, 19% had CLD, including 15.2% with NAFLD. Patients with CLD had longer length of stay. After controlling for age, gender, obesity, cardiac diseases, hypertension, hyperlipidemia, diabetes, and pulmonary disorders, CLD and NAFLD were independently associated with ICU admission [(aOR 1.77, 95% CI 1.03-3.04) and (aOR 2.30, 95% CI 1.27-4.17)] and mechanical ventilation [(aOR 2.08, 95% CI 1.20-3.60) and (aOR 2.15, 95% CI 1.18-3.91)]. Presence of cirrhosis was an independent predictor of mortality (aOR 12.5, 95% CI 2.16-72.5). Overall, nearly one-fifth of hospitalized COVID-19 patients had CLD, which was associated with more critical illness. Future studies are needed to identify interventions to improve clinical outcomes.
PMID: 32585065 [PubMed - as supplied by publisher]