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Patient Reported Outcome Measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review.
Eur Respir J. 2019 Jan 11;:
Authors: Pick HJ, Bolton CE, Lim WS, McKeever TM
Abstract
Symptomatic and functional recovery are important patient-reported outcome measures (PROMs) in community-acquired pneumonia (CAP) that are increasingly used as trial endpoints. This systematic review summarises the literature on PROMs in CAP.Comprehensive searches in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement were conducted to March 2017. Eligible studies included adults discharged from hospital following confirmed CAP and reporting PROMs.Fifteen studies (n=5644 patients) were included; most of moderate quality. Studies used a wide range of PROMs and assessment tools. At 4-6 weeks' post-discharge, the commonest symptom reported was fatigue (45% to 72.6% of patients, 3 studies), followed by cough (35.3% to 69.7%) and dyspnoea (34.2% to 67.1%), corresponding values from studies restricted by age <65 years (2 studies) were lower; fatigue 12.1% to 25.7%, cough 19.9% to 31.9%, dyspnoea 16.8% to 27.5%. Functional impairment 4 weeks post-discharge was reported in 18% to 51% of patients (2 studies) while median time to return to normal activities was between 15 to 28 days (3 studies).Substantial morbidity is reported by patients up to 6 weeks post-discharge. There is weak methodological consistency across existing studies. A core set of PROMs for use in future studies is suggested.
PMID: 30635298 [PubMed - as supplied by publisher]