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Ceftaroline Activity Tested against Bacterial Pathogens Frequently Isolated in United States (USA) Medical Centers: Results from 5 Years of AWARE Surveillance Program.
Antimicrob Agents Chemother. 2015 Feb 2;
Authors: Sader HS, Flamm RK, Streit J, Farrell DJ, Jones RN
Abstract
A total of 84,704 isolates were collected from 191 medical centers in 2009-2013 and tested for susceptibility to ceftaroline and comparator agents by broth microdilution methods. Ceftaroline inhibited all Staphylococcus aureus at ≤2 μg/mL and was very active against methicillin-resistant strains (MIC90, 1 μg/mL; 97.6% susceptible). Among Streptococcus pneumoniae, the highest ceftaroline MIC was 0.5 μg/mL and ceftaroline activity against the most common Enterobacteriaceae (MIC50, 0.12 μg/mL; 78.9% susceptible) was similar to ceftriaxone (MIC50, ≤0.25 μg/mL; 86.8% susceptible).
PMID: 25645844 [PubMed - as supplied by publisher]