Examining the Use of Ceftaroline in the Treatment of Streptococcus pneumoniae Meningitis with Reference to Human Cathelicidin LL-37.
Antimicrob Agents Chemother. 2015 Jan 20;
Authors: Sakoulas G, Nonejuie P, Kullar R, Pogliano J, Rybak MJ, Nizet V
Five cases of bacterial meningitis treated with ceftaroline (4 S. pneumoniae; 1 S. aureus) are summarized. The pharmacodynamics between cathelicidin LL-37 and ceftaroline are evaluated against S. pneumoniae. Patients who received ceftaroline 600 mg q8hr (1 S. aureus; 3 S. pneumoniae) were successfully treated; 1 patient with S. pneumoniae who received 600 mg q12hr failed. Ceftaroline increased negative surface charge and sensitized S. pneumoniae to killing by LL-37, a peptide implicated in blood-brain barrier defense.
PMID: 25605351 [PubMed - as supplied by publisher]