Acute kidney injury due to rhabdomyolysis and renal replacement therapy: a critical review.
Crit Care. 2014 May 28;18(3):224
Authors: Petejova N, Martinek A
Abstract
Rhabdomyolysis, a clinical syndrome caused by damage to skeletal muscle and release of its breakdown products into the circulation, can be followed by acute kidney injury (AKI) as a severe complication. The belief that the AKI is triggered by myoglobin as the toxin responsible appears to be oversimplified. Better knowledge of the pathophysiology of rhabdomyolysis and following AKI could widen treatment options, leading to preservation of the kidney: the decision to initiate renal replacement therapy in clinical practice should not be made on the basis of the myoglobin or creatine phosphokinase serum concentrations.
PMID: 25043142 [PubMed - as supplied by publisher]