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Valve surgery in active infective endocarditis: A simple score to predict in-hospital prognosis.
Int J Cardiol. 2014 May 9;
Authors: Martínez-Sellés M, Muñoz P, Arnáiz A, Moreno M, Gálvez J, Rodríguez-Roda J, de Alarcón A, García Cabrera E, Fariñas MC, Miró JM, Montejo M, Moreno A, Ruiz-Morales J, Goenaga MA, Bouza E, on behalf of the Spanish Collaboration on Endocarditis — Grupo de Apoyo al Manejo de la Endocarditis infecciosa en ESpaña (GAMES) (see Appendix 1).
Abstract
AIMS: Surgery for infective endocarditis (IE) is associated with high mortality. Our objectives were to describe the experience with surgical treatment for IE in Spain, and to identify predictors of in-hospital mortality.
METHODS: Prospective cohort of 1000 consecutive patients with IE. Data were collected in 26 Spanish hospitals.
RESULTS: Surgery was performed in 437 patients (43.7%). Patients treated with surgery were younger and predominantly male. They presented fewer comorbid conditions and more often had negative blood cultures and heart failure. In-hospital mortality after surgery was lower than in the medical therapy group (24.3 vs 30.7%, p=0.02). In patients treated with surgery, endocarditis involved a native valve in 267 patients (61.1%), a prosthetic valve in 122 (27.9%), and a pacemaker lead with no clear further valve involvement in 48 (11.0%). The most common aetiologies were Staphylococcus (186, 42.6%), Streptococcus (97, 22.2%), and Enterococcus (49, 11.2%). The main indications for surgery were heart failure and severe valve regurgitation. A risk score for in-hospital mortality was developed using 7 prognostic variables with a similar predictive value (OR between 1.7 and 2.3): PALSUSE: prosthetic valve, age≥70, large intracardiac destruction, Staphylococcus spp, urgent surgery, sex [female], EuroSCORE≥10. In-hospital mortality ranged from 0% in patients with a PALSUSE score of 0 to 45.4% in patients with PALSUSE score >3.
CONCLUSIONS: The prognosis of IE surgery is highly variable. The PALSUSE score could help to identify patients with higher in-hospital mortality.
PMID: 24852838 [PubMed - as supplied by publisher]