Statins use and risk of mortality in patient with Clostridium difficile infection.

Link to article at PubMed

Statins use and risk of mortality in patient with Clostridium difficile infection.

Clin Microbiol Infect. 2014 May 11;

Authors: Saliba W, Barnett-Griness O, Elias M, Rennert G

Current evidence suggests that statins may improve outcome in infectious diseases. This study aims to assess whether statins use is associated with reduced risk of 30-day mortality in Clostridium difficile infection (CDI). Using the computerized database of Clalit, the largest health care provider in Israel, we identified a cohort of adult subjects (age ≥40 years) who tested positive on a Clostridium difficile toxin assay performed between January-2011 and December-2012. Subjects were defined as current statins users if they filled at least one prescription during the 90 days prior to the laboratory assay date. Current users were classified into long-term users if at least one additional prescription was filled during the prior 91-180 days; otherwise they were defined as short-term users. A total 1,888 patients with CDI were included. Of them, 340 (18.0%) died during the first 30-days after diagnosis. The 30-day mortality rate was lower among current statins users 89/669 (13.3%) compared to 251/1219 (20.6%) in non-users (P<0.001). A significant reduced risk of 30-day mortality consisted after adjustment for potential confounders; adjusted OR= 0.57 (95% CI, 0.42-0.79) and was unique to long-term users; 0.53 (0.38-0.73) but not short-term users; 1.15 (0.56-2.34). The risk of 30-day mortality decreased with increasing the number of filled statins prescriptions; adjusted OR= 0.77 (0.67-0.89) for each additional prescription. Current Aspirin use was also independently associated with reduced mortality; adjusted OR= 0.64(0.43-0.88). In conclusion, current statins use, particularly long-term use, has a dose response protective effect on mortality in patients with CDI. This article is protected by copyright. All rights reserved.

PMID: 24816303 [PubMed - as supplied by publisher]

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