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Oritavancin Activity Against Staphylococcus aureus Causing Invasive Infections in USA and European Hospitals. A five-year International Surveillance Program.
Antimicrob Agents Chemother. 2014 Feb 18;
Authors: Mendes RE, Sader HS, Flamm RK, Farrell DJ, Jones RN
Abstract
Oritavancin had modal MIC, MIC50 and MIC90 values of 0.03, 0.03 and 0.06 μg/ml against S. aureus, respectively. Similar results (MIC50/90, 0.03/0.06 μg/ml) were observed against methicillin-resistant and -susceptible isolates and those demonstrating multidrug resistance (MDR) and non-MDR phenotypes. Oritavancin (MIC50/90, 0.06/0.12 μg/ml) tested against S. aureus with elevated MIC values for daptomycin (i.e. 1 - 4 μg/ml) and vancomycin (i.e. 2 μg/ml) showed MIC results two-fold higher than the respective susceptible counterparts (MIC50/90, 0.03/0.06 μg/ml), yet inhibiting these isolates at ≤0.25 μg/ml.
PMID: 24550323 [PubMed - as supplied by publisher]