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Low-Dose Aspirin and Upper Gastrointestinal Bleeding in Primary Versus Secondary Cardiovascular Prevention: A Population-Based, Nested Case-Control Study.
Circ Cardiovasc Qual Outcomes. 2013 Nov 19;
Authors: Lin KJ, De Caterina R, Rodríguez LA
Abstract
BACKGROUND: value for the difference=0.0014) prevention cohort. However, as the baseline risk of UGIB was lower in the primary than in the secondary prevention cohort, numbers needed to harm per 1 year of low-dose aspirin use were 601 and 391 for primary and secondary prevention, respectively.Conclusions-The relative risk of UGIB in patients taking low-dose aspirin is higher when used for primary than for secondary cardiovascular disease prevention, but this difference is more than compensated by the lower baseline risk in the primary prevention population. Such estimates are important for an assessment of the net clinical benefit in primary prevention.
PMID: 24254886 [PubMed - as supplied by publisher]