2023 Aug 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–.
ABSTRACT
Valproic acid (VPA) ia as a highly prevalent medication with multifaceted therapeutic applications in various neurological and psychiatric disorders. The therapeutic uses of VPA include epilepsy treatment across different seizure types, bipolar disorder management, and migraine prophylaxis. The mechanism of action for VPA involves the enhancement of inhibitory neurotransmission and the modulation of voltage-gated ion channels. Coordination among interprofessional healthcare professionals, including neurologists, psychiatrists, pharmacists, and nurses, is crucial for appropriate patient selection, dosage adjustment, and monitoring of VPA therapy. This activity analyzes and assesses the indications, pharmacology, potential drug interactions, and adverse effects of VPA therapy, encompassing its effectiveness across various clinical scenarios. Furthermore, this activity also critically reviews the evidence supporting VPA's application in specific populations, including pediatric patients, pregnant women, and older individuals. The assessment also delves into the effectiveness of communication among healthcare providers, patients, and caregivers, regarding the advantages, potential risks, and adherence to VPA treatment.