Hypoglycaemia incidence with a simple, low-dose insulin protocol for adult diabetic ketoacidosis

Link to article at PubMed

Int J Pharm Pract. 2022 May 30:riac046. doi: 10.1093/ijpp/riac046. Online ahead of print.


OBJECTIVE: The objective of this study is to validate the glycaemic safety of a simple insulin protocol using weight-based insulin rates adapted from American guidance for the management of adult diabetic ketoacidosis.

METHODS: Measures of hypoglycaemia were retrospectively assessed in a single cohort of inpatient adults. The primary outcome was incidence of hypoglycaemia during insulin infusion.

KEY FINDINGS: Hypoglycaemia during infusion occurred in 6/81 patients (7% [95% CI 3-16%]). Five of these occurrences were associated with protocol nonadherence.

CONCLUSIONS: The glycaemic safety of a novel, variable-rate insulin protocol directly incorporating weight-based infusion rates is supported by this single-centre study.

PMID:35652466 | DOI:10.1093/ijpp/riac046

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