Int J Pharm Pract. 2022 May 30:riac046. doi: 10.1093/ijpp/riac046. Online ahead of print.
OBJECTIVE: The objective of this study is to validate the glycaemic safety of a simple insulin protocol using weight-based insulin rates adapted from American guidance for the management of adult diabetic ketoacidosis.
METHODS: Measures of hypoglycaemia were retrospectively assessed in a single cohort of inpatient adults. The primary outcome was incidence of hypoglycaemia during insulin infusion.
KEY FINDINGS: Hypoglycaemia during infusion occurred in 6/81 patients (7% [95% CI 3-16%]). Five of these occurrences were associated with protocol nonadherence.
CONCLUSIONS: The glycaemic safety of a novel, variable-rate insulin protocol directly incorporating weight-based infusion rates is supported by this single-centre study.
PMID:35652466 | DOI:10.1093/ijpp/riac046