Prognosis of hospitalized patients with cirrhosis and acute kidney disease

Link to article at PubMed

Liver Int. 2022 Jan 12. doi: 10.1111/liv.15154. Online ahead of print.


The prognosis of acute kidney disease (AKD), defined as a glomerular filtration rate of <60ml/min/1.73m2 or a rise in serum creatinine (sCr) of <50% for <3 months, is not clearly known.

AIM: To study the prevalence, predictive factors and clinical outcomes in hospitalized cirrhotic patients with AKD.

METHODS: The North American Consortium for the Study of End-Stage Liver Disease prospectively enrolled hospitalized decompensated cirrhotic patients. Patients were separated into those with normal renal function (controls or C), AKD or stage 1 AKI as their worst renal dysfunction per International Club of Ascites definition and compared. Parameters assessed included demographics, laboratory data, hemodynamics, renal and patient outcomes.

RESULTS: 1244 patients with cirrhosis and ascites (C: 704 or 57%; AKD: 176 or 14%; stage 1 AKI: 364 or 29%) with similar demographics were enrolled. AKD patients had similar baseline sCr, but higher hospital admission in previous 6 months, and higher peak sCr, compared to controls, with their peak sCr being lower than that in stage 1 AKI patients (all p<0.0001). The in-hospital and 30-day survival for AKD patients were intermediary between that for controls and stage 1 AKI patients (96% vs. 91% vs. 86%, p<0.0001). The strongest predictors for AKD development while in hospital were the presence of a second infection (OR: 2.44) and diabetes (OR: 1.53).

CONCLUSIONS: Patients with AKD had intermediate outcomes between stage 1 AKI and controls. AKD patients, especially those with diabetes and a second infection, need careful monitoring and prompt treatment for AKD to prevent negative outcomes.

PMID:35023264 | DOI:10.1111/liv.15154

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