Messenger Ribonucleic Acid Vaccines for Severe Acute Respiratory Syndrome Coronavirus-2 – A Review

Link to article at PubMed

Transl Res. 2021 Dec 22:S1931-5244(21)00304-2. doi: 10.1016/j.trsl.2021.12.007. Online ahead of print.


The mRNA therapeutics have been studied since the 1970s and the currently available mRNA vaccines against COVID-19 are the culmination of decades of scientific research. The mRNA vaccines BNT162b2 and mRNA-1273 have played a key role in our global response to the COVID-19 pandemic as they have demonstrated significant advantages over conventional vaccines and have proven to be highly effective against COVID-19 associated hospitalization and severe illness in large clinical trials and studies using real-world data.

PMID:34954088 | DOI:10.1016/j.trsl.2021.12.007

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