J Med Virol. 2021 Aug 18. doi: 10.1002/jmv.27277. Online ahead of print.
Due to the known anti-inflammatory and antiviral effects of zinc, 25(OH)D, and vitamin B12, in this study, we explored the association between serum levels of these micronutrients in COVID-19 patients at the time of admission and clinical outcomes. This study carried out on 293 patients with COVID-19 who were hospitalized at Imam Hassan hospital (Bojnourd, Iran). We collected demographic data, clinical characteristics, values of serum biochemical parameters in the first week of admission, and clinical outcomes from electronic medical records. We also measured serum levels of zinc, 25(OH)D, and vitamin B12 within three days of admission. Of 293 hospitalized, the median age was 53 years, and 147 (50.17%) were female. Thirty-seven patients (12.62%) admitted to the ICU, and forty-two (14.32%) died. We found that serum levels of zinc, vitamin B12, and 25(OH)D are lower in patients who died than those who admitted to ICU or non-ICU and survived; however, these differences were not statistically significant for vitamin B12 and 25(OH)D (P>0.05). The serum concentrations of zinc, vitamin B12, and 25(OH)D at the time of admission did not affect the length of hospital stay in COVID-19 patients. In general, it seems that serum levels of 25(OH)D, vitamin B12, and especially zinc at the time of admission can affect clinical outcomes in COVID-19 patients. This article is protected by copyright. All rights reserved.